ErbB1 -> Akt1 ErbB2_3 -> Akt1 IGF1R -> Akt1 ErbB1_2 -> Akt1 ErbB1_3 -> Akt1 ErbB3 -> ErbB2_3 ErbB2 -> ErbB2_3 ErbB1 -> ErbB1_3 ErbB3 -> ErbB1_3 EGF -> ErbB1 p21 -| CDK4 p27 -| CDK4 CycD1 -> CDK4 EGF -> ErbB2 ErbB1 -> ErbB1_2 ErbB2 -> ErbB1_2 cMYC -> CycE1 EGF -> ErbB3 MEK1 -> CycD1 ERa -> CycD1 cMYC -> CycD1 Akt1 -> CycD1 CycD1 -> CDK6 CycE1 -> CDK2 p21 -| CDK2 p27 -| CDK2 ERa -> p27 cMYC -| p27 CDK2 -| p27 CDK4 -| p27 Akt1 -| p27 ErbB1 -> MEK1 ErbB2_3 -> MEK1 ErbB1_2 -> MEK1 IGF1R -> MEK1 ErbB1_3 -> MEK1 MEK1 -> ERa Akt1 -> ERa ERa -> cMYC MEK1 -> cMYC Akt1 -> cMYC CDK2 -> pRB CDK4 -> pRB CDK6 -> pRB ERa -> IGF1R ErbB2_3 -| IGF1R Akt1 -> IGF1R ERa -> p21 cMYC -| p21 CDK4 -| p21 Akt1 -| p21 $Akt1: ((((ErbB2_3 | IGF1R) | ErbB1_2) | ErbB1) | ErbB1_3) $CDK2: (CycE1 & !(p21 | p27)) $CDK4: (CycD1 & !(p27 | p21)) $CDK6: CycD1 $CycD1: ((Akt1 & (cMYC & ERa)) | (MEK1 & (ERa & cMYC))) $CycE1: cMYC $ERa: (Akt1 | MEK1) $ErbB1: EGF $ErbB1_2: (ErbB1 & ErbB2) $ErbB1_3: (ErbB1 & ErbB3) $ErbB2: EGF $ErbB2_3: (ErbB2 & ErbB3) $ErbB3: EGF $IGF1R: ((Akt1 & !ErbB2_3) | (ERa & !ErbB2_3)) $MEK1: ((((ErbB2_3 | IGF1R) | ErbB1) | ErbB1_3) | ErbB1_2) $cMYC: ((Akt1 | ERa) | MEK1) $p21: (ERa & !((CDK4 | Akt1) | cMYC)) $p27: (ERa & !(((CDK2 | CDK4) | Akt1) | cMYC)) $pRB: ((CDK2 & (CDK4 & CDK6)) | (CDK4 & CDK6))